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Highly sensitive and specific molecular detection is essential for advancing early cancer diagnosis. In this paper, we present an imaging system that combines swept source Raman spectroscopy with surface-enhanced Raman scattering (SERS) nanoparticles to enhance cancer detection capability. By incorporating a high-efficiency superconducting nanowire single-photon detector (SNSPD), the system achieves remarkable detection sensitivity to the femtomolar concentrations. This performance was demonstrated under practical conditions using only 30 mW excitation power and 40 ms wavelength point exposure time, enabling ultra-sensitive acquisition. Imaging experiments on both cell and tissue samples confirm the system’s compatibility with various biological applications. Combining high sensitivity, speed, and specificity, this platform offers a promising approach for molecular imaging and early stage cancer detection using SERS-based probes. 

The field of Autonomous Driving (AD) has witnessed significant progress in recent years. Among the various challenges faced, the safety evaluation of autonomous vehicles (AVs) stands out as a critical concern. Traditional evaluation methods are both costly and inefficient, often requiring extensive driving mileage in order to encounter rare safety-critical scenarios, which are distributed on the long tail of the complex real-world driving landscape. In this paper, we propose a unified approach, Diffusion-Based Safety-Critical Scenario Generation (DiffScene), to generate high-quality safety-critical scenarios which are both realistic and safety-critical for efficient AV evaluation. In particular, we propose a diffusion-based generation framework, leveraging the power of approximating the distribution of low-density spaces for diffusion models. We design several adversarial optimization objectives to guide the diffusion generation under predefined adversarial budgets. These objectives, such as safety-based objective, functionality-based objective, and constraint-based objective, ensure the generation of safety-critical scenarios while adhering to specific constraints. Extensive experimentation has been conducted to validate the efficacy of our approach. Compared with 6 SOTA baselines, DiffScene generates scenarios that are (1) more safety-critical under 3 metrics, (2) more realistic under 5 distance functions, and (3) more transferable to different AV algorithms. In addition, we demonstrate that training AV algorithms with scenarios generated by DiffScene leads to significantly higher performance in terms of the safety-critical metrics compared to baselines. These findings highlight the potential of DiffScene in addressing the challenges of AV safety evaluation, paving the way for safer AV development. 

Multi-sensor fusion systems (MSFs) play a vital role as the perception module in modern autonomous vehicles (AVs). Therefore, ensuring their robustness against common and realistic adversarial semantic transformations, such as rotation and shifting in the physical world, is crucial for the safety of AVs. While empirical evidence suggests that MSFs exhibit improved robustness compared to single-modal models, they are still vulnerable to adversarial semantic transformations. In addition, although many empirical defenses have been proposed, several works show that these defenses can be further attacked by new adaptive attacks. So far, there is no certified defense proposed for MSFs. In this work, we propose the first robustness certification framework COMMIT to certify the robustness of multi-sensor fusion systems against semantic attacks. In particular, we propose a practical anisotropic noise mechanism that leverages randomized smoothing on multi-modal data and performs a grid-based splitting method to characterize complex semantic transformations. We also propose efficient algorithms to compute the certification in terms of object detection accuracy and IoU for large-scale MSF models. Empirically, we evaluate the efficacy of COMMIT in different settings and provide a comprehensive benchmark of certified robustness for different MSF models using the CARLA simulation platform. We show that the certification for MSF models is at most 48.39% higher than that of single-modal models, which validates the advantages of MSF models. We believe our certification framework and benchmark will contribute an important step towards certifiably robust AVs in practice.